Molecular Formula | C21H30Cl2N2O5 |
Molar Mass | 461.38 |
Density | 1.233±0.06 g/cm3(Predicted) |
Melting Point | 113-115℃ |
Boling Point | 632.2±55.0 °C(Predicted) |
Solubility | DMSO: ≥5mg/mL |
Appearance | powder |
Color | white to beige |
pKa | pKa ~5(at 25℃) |
Storage Condition | 2-8°C |
In vivo study | The effects of pancreatic rest by oral administration of CCK-1 receptor antagonist Loxiglumide and pancreas stimulation are investigated via endogenous CCK release induced by po protease inhibitor camostat on the recovery of pancreatic secretory function, and biochemical and histological changes of the pancreas after acute hemorrhagic pancreatitis. Oral administration of CCK-1 receptor antagonist Loxiglumide with a dose of 50 mg/kg body weight inhibits pancreatic exocrine secretion for more than 12 h. Thus, every 12-h administration of Loxiglumide might have completely blocks the effect of endogenously released CCK on the pancreas (pancreatic rest). |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.167 ml | 10.837 ml | 21.674 ml |
5 mM | 0.433 ml | 2.167 ml | 4.335 ml |
10 mM | 0.217 ml | 1.084 ml | 2.167 ml |
5 mM | 0.043 ml | 0.217 ml | 0.433 ml |